Mycobacterial (Tuberculosis) Therapeutics



  1. Hughes, M.A., C.A. Townsend. New a-Methylene y-Butyrolactones with Antimycobacterial Properties. Bioorg. Med. Chem. Lett., 15, 3857-3859, 2005.

  2. Parrish, N.M., C.G. Ko, J.D. Dick, P.B. Jones, and J.L.E. Ellingson. Growth, congo red agar colony morphotypes and antibiotic susceptibility testing of mycobacterium avium subspecies paratuberculosis. Clin. Med. Research II: 107-114, 2004.

  3. Parrish, N.M., C.G. Ko, M.A. Hughes, C.A. Townsend, and J.D. Dick. Effect of N-octanesulphonylacetamide (OSA) on ATP and protein expression in mycobacterium bovis BCG. J. Antimicrob. Chemother. 54(4): 722-729, 2004.

  4. Udwary DW, Merski M, Townsend CA. A Method for Prediction of Linker Regions within Large Multifunctional Proteins, and its Application to a Type I Polyketide Synthase. J. Mol. Biol. 323, 585-598, 2002.

  5. Hendrix, C.W., Hammond, J.M., Swoboda, S.M., Merz, W.G., Harrington, S.M., Perl, T.M., Dick, J.D., Borschel, D.M., Halczenko, P.W., Pelz, R.K., Rocco, L.E., Conway, J.E., Brower, R.G., Lipsett, P.A. Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients. Ann Surg. 233(2):259-265, 2001.

  6. Miller, M.T. Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nat Struct Biol. 8(8):684-689, 2001.

  7. Parrish, N.M., Houston, T., Jones, P.B., Townsend, C., Dick, J.D. In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrob Agents Chemother. 45(4):1143-1150, 2001.

  8. Zhou, J., Kelly, W.L., Bachmann, B.O., Gunsior, M., Townsend, C.A., Solomon, E.I. Spectroscopic studies of substrate interactions with clavaminate synthase 2, multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. J Am Chem Soc. 123(30):7388-7398, 2001.

  9. Bachmann, B.O., Townsend, C.A. Kinetic mechanism of the beta lactam synthetase of Streptomyces clavulige. Biochemistry 39(37):11187-11193, 2000.

  10. Dannenberg, A.M., Bishai, W.R., Parrish, N., Ruiz, R., Johnson, W., Zook, B.C., Boles, J.W., Pitt, L.M. Efficacies of BCG and vole bacillus (Mycobacterium microti) vaccines in preventing clinically apparent pulmonary tuberculosis in rabbits: a prelimin report. Vaccine 19(7-8):796-800, 2000.

  11. Jones, P. B., Parrish, N. M., Houston, T. A., Stapon, A. S., Bansai, N. P., Dick, J. D., and Townsend, C. A. A new class of anti-tuberculosis agents, Journal Medicinal Chemistry. 43(17):3304-3314, 2000.

  12. Khaleeli, N., Busby, R.W., Townsend, C.A. Site-directed nutagenesis and biochemical analysis of the endogenous ligar the ferrous active site of clavaminate synthase. The His-3 variant of the 2-H carboxylate model. Biochemistry 39(29):8666-8673, 2000.

  13. Li, R., Khaleeli, N., Townsend, C.A. Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulan by Streptomyces clavuligerus. J Bacteriol. 182(14):4087-4095, 2000.

  14. Bishai, W.R., Dannenberg, A.M., Jr., Parrish, N., Ruiz, R., Chen, P., Zook, B.C., Johnson, W., Boles, J.W., Pitt, M.L. Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits elevated by Lurie's pulmonary tubercle count method. Infect Immun. 67(9);4931-4934, 1999.

  15. Parrish NM, Kuhajda FP, Heine HS, Bishai WR, and Dick JD. Antimycobacterial activity of cerulenin and its effects on lipid biosynthesis, J. Antimicrobial Chemotherapy. 43: 219-226, 1999.

  16. Rastogi N, Goh KS, Horgen L, and Barrow WW. Synergistic activities of antituberculosis drugs with cerulenin and trans-cinnamic acid against Mycobacterium, FEMS Immunology & Medical Microbiology. 21: 149-157, 1998.
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