Cancer Therapeutics



  1. Alli, PM, Pinn ML, Jaffee EM, McFadden JM, Kuhajda FP. Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene. 24, 39-46, 2005.

  2. McFadden JM, Medghalchi SM, Thupari JN, Pinn ML, Vadlamudi A, Miller KI. Application of a flexible snythesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. J Med Chem. 24;48(4):946-61, 2005.

  3. Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Cristofano A, Testa JR. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene. 24(22):3574-82, 2005.

  4. Wang YY, Kuhajda FP, Li J, Finch TT, Cheng P, Koh C, Li T, Sokoll LJ, Chan DW. Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer. J Exp Ther Oncol. 4(2):101-10, 2004.

  5. McFadden JM, Frehywot GL, Townsend CA. A Flexible Route to (5R)-Thiolactomycin, a Naturally-Occurring Inhibitor of Fatty Acid Synthesis. Org. Lett., 4, 3859-3862, 2002.

  6. Gabrielson, E. W., Pinn, M. L., Testa, J. R., and Kuhajda, F. P. Increased Fatty Acid Synthase is a Therapeutic Target in Mesothelioma, Clinical Cancer Research. 7: 153-157, 2001.

  7. Li, J.N., Gorospe, M., Chrest, F.J., Kumaravel, T.S., Evans, M.K., Han, W.F., Pizer, E.S. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res. 61(4):1493-1499, 2001.

  8. Pizer, E.S., Pflug, B.R., Bova, G.S., Han, W.F., Udan, M.S., Nelson, J.B. Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. Prostate. 47(2):102-110, 2001.

  9. Thupari, J.N., Pinn, M.L., Kuhajda, F.P. Fatty acid synthase inhibition in human breast cancer cells leands to malonyl-CoA- induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 285(2):217-223, 2001.

  10. Hough, C.D., Sherman-Baust, C.A., Pizer, E.S., Montz, F.J., Im, D.D., Rosenshein, N.B., Cho, K.R., Riggins, G.J., Morin, P.J. Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res. 60(22):6281-6287, 2000.

  11. Kuhajda, F.P. Fatty-acid synthase and human cancer: new perspectives on its role in tumo biology. Nutrition. 16(3):202-208, 2000. Review.

  12. Kuhajda, F. P., Pizer, E. P., Li, J. L., Mani, N. S., Frehywot, G. L., and Townsend, C. A. Synthesis and anti-tumor activity of a novel inhibitor of fatty acid synthase, Proceedings of the National Academy of Science (USA). 97: 3450-3454, 2000.

  13. Lax, S.F., Kurman, R.J., Pizer, E.S., Wu, L., Ronnett, B.M. A binary architectural grading system for uterine endometrial endometrioid carcinoma has superior reproducibility compared with FIGO grading and identifies subsets of advance-stage tumors with favorable and unfavorable prognosis. Am J Surg Pathol. 24(9):1201-1208, 2000.

  14. Li, J.N., Mahmoud, M.A., Han, W.F., Ripple, M., Pizer, E.S. Sterol regulatory element-binding protein-1 participates in the regulation of acid synthase expression in colorectal neoplasia. Exp Cell Res. 261(1):159-165, 2000.

  15. Lin, H., Pizer, E.H., Morin, P.J. A frequent deletion polymorphism on chromosome 22q13 identified by representational difference analysis of ovarian cancer. Genomics 69(3):391-394, 2000.

  16. Pizer, E. S., Thupari, J., Han, W. F., Pinn, M. L., Chrest, F. J., Frehywot, G. L., Townsend, C. A., and Kuhajda, F. P. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty acid synthase inhibition in human breast cancer cells and xenografts, Cancer Research. 60: 213-218, 2000.

  17. Pizer, E. S., Pflug, B. R., Bova, G. S., Han, W. F., Udan, M. S., and Nelson, J. B. Increase fatty acid synthase as a therapeutic target in androgen independent prostate cancer progression, Proceedings of the American Association of Cancer Research. 41: 655, 2000.

  18. Wilentz, R.E., Witters, L.A., Pizer, E.S. Lipogenic enzymes fatty acid synthase and acetyl-coenzyme A carboxylase coexpressed with sterol regulatory element binding protein and Ki-67 in fetal tissues. Pediatr Dev Pathol. 3(6):525-531, 2000.

  19. Furlong, M.T., Hough, C.D., Sherman-Baust, C.A., Pizer, E.S., Morin, P.J. Evidence for the colonic origin of ovarian cancer cell line SW626. J Natl Cancer Inst. 91(15):1327-1328, 1999. No abstract available.

  20. Mahmoud MA, Brody JR, and Pasternack GR. Transcriptional regulation of fatty acid synthase (FAS) in breast cancer, Proceeding of the American Association for Cancer Research. 40: 365, 1999.

  21. Myers RB, Oelschlager DK, Frost A, and Grizzle WE. Expression of fatty acid synthetase during castration induced regression of prostatic adenocarcinoma, Proceeding of the American Association for Cancer Research. 40: 65, 1999.

  22. Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A., and Han, W. F. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines, Cancer Research. 58: 4611-4615, 1998.

  23. Pizer ES, Lax SF, Kuhajda FP, Pasternak GR, Kurman RJ. Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors. Cancer. 83(3):528-37, 1998.

  24. Swinnen, J., Esquenet, M., Goossens, K., Heyns, W., and Verhoeven, G. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP, Cancer Research. 57: 1086-1090, 1997.

  25. Swinnen, J. V., Ulrix, W., Heyns, W., and Verhoeven, G. Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins, Proc. Natl. Acad. Sci. 94: 12975-12980, 1997.

  26. Pizer, E. S., Wood, F. D., Pasternack, G. R., and Kuhajda, F. P. Fatty acid synthase (FAS): A target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells, Cancer Research. 1996: 745-751, 1996.

  27. Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., and Kuhajda, F.P. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells, Cancer Research. 56: 2745-2747, 1996.

  28. Pizer, E. S., Wood, F. D., Heine, H. S., Romantsev, F. R., Pasternack, G. R., and Kuhajda, F. P. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer, Cancer Research. 56: 1189-1193, 1996.

  29. Swinnen, J., Van Veldhoven, P., Edquenet, M., Heyns, W., and Verhoeven, G. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP, Endocrinology. 137: 4468-4474, 1996.

  30. Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., and Pasternack, G. R. Fatty acid synthesis: a potential selective target for antineoplastic therapy, Proceedings of the National Academy of Science. 91: 6379-6383, 1994.

  31. Witters, L., Widmer, J., King, A., Fassihi, K., and Kuhajda, F. Identification of human acetyl-CoA carboxylase isozymes in tissue and in breast cancer cells, International Journal of Biochemistry. 26: 589-594, 1994.
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