Obesity and Diabetes Therapeutics



  1. Kim EF, Miller I, Aja S, Landree LE, Pinn M, McFadden J, Kuhajda FP, Moran TH, Ronnett GV. C75, a fatty acid synthase inhibitor, reducesfood intake via hypothalamic AMP-activated protein kinase. J Biol Chem. 279(19):19970-6, 2004.

  2. Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. J Biol Chem. 279(5):3817-27, 2004.

  3. Aja S, Robinson BM, Mills KJ, Ladenheim EE, Moran TH. Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats. Behav Neurosci. 2002 Oct; 116(5):918-21.

  4. Bi S, Moran TH. Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat. Neuropeptides, April/June 2002, 36(2/3):171-181.

  5. Kim EK, Miller I, Landree LE, Borisy-Rudin FF, Brown P, Tihan T, Townsend CA, Witters LA, Moran TH, Kuhajda FP, Ronnett GV. Expression of Fatty Acid Synthase within Hypothalamic Neurons: A Putative Model for Decreased Food Intake Following C75 Treatment. Am. J. Physiol Endocrinol Metab 283:E867-E879, 2002.

  6. Ladenheim EE, Hampton LL, Whitney AC, White WO, Battey JF, Moran TH. Disruptions in feeding and body weight control in gastrin-releasing peptide receptor knockout mice. J Endocrinol. 2002 Aug; 174(2):273-81.

  7. Moon C, Yoo JY, Matarazzo V, Sung YK, Kim E, Ronnett GV. (2002) Leukemia Inhibitory Factor is a regulator of olfactory receptor neuronal maturation. PNAS USA 99: 9015-9020.

  8. Moran TH, Lee P, Ladenheim EE, Schwartz GJ. Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors. Physiol Behav. 2002 Mar;75(3):397-402.

  9. Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone KM. Effects of genetic background on neonatal Borna disease virus (BDV) infection-induced neurodevelopmental damage: I. Brain pathology and behavioral deficits. Brain Res. 2002 Jul 19;944(1-2):97-107.

  10. Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone, K.M. Effects of genetic background on neonatal Borna disease virus (BDV) infection-induced neurodevelopmental damage: II. Neurochemical alterations and responses to pharmacological treatments. Brain Res. 2002 Jul 19;944(1-2):108-23.

  11. Schwartz GJ, Moran TH. Leptin and NPY have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake. Endocrinology. 2002 Oct; 143(10):3779-84.

  12. Seeley RJ, Moran TH. Principles for interpreting interactions among the multiple systems that influence food intake. Am J Physiol Regul Integr Comp Physiol. 2002 Jul;283(1):R46-53. Review.

  13. Simpson J, Miller IL, Moon C, Liebl D, Ronnett GV. (2002) Atrial Natriuretic Peptide Type C (CNP) Induces a Cell Cycle Switch from Proliferation to Differentiation in Neurotrophin-Primed Olfactory Receptor Neurons. J Neurosci. 22: 5536-5551.

  14. Sung YK, Moon C, Yoo JY, Pevsner J, Ronnett GV. (2002) Plunc, a Member of the Secretory Gland Protein Family, Is Up-regulated in Nasal Respiratory Epithelium after Olfactory Bulbectomy. J. Biol. Chem 277:12762-1276.

  15. Thupari JN, Landree LE, Ronnett GV, Kuhajda FP. C75 increases Peripheral Energy Utilization and Fatty Acid Oxidation in Diet-Induced Obesity. PNAS 99:9498-9502, 2002.

  16. Aja S, Sahandy S, Ladenheim EE, Schwartz GJ, Moran TH. Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site. Am J Physiol Regul Integr Comp Physiol. 2001 Dec;281(6):R1862-7.

  17. Aja, S., Schwartz, G.J., Kuhar, M.J., Moran, T.H. Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure. Am J Physiol Regul Integr Comp Physiol. 280(6):R1613-9,2001.

  18. Bi, S., Ladenheim, E.E., Schwartz, G.J., Moran, T.H. A role for NPY overexpression I the dorsomedical hypothalamus in hyperphagia and obesity of OLETF rats. Am J Physiol Regul Integr Comp Physiol. 281(1):R254-60, 2001.

  19. Coluntuoni C, Schwenker J, McCarthy J, Rada P, Ladenheim B, Cadet JL, Schwartz GJ, Moran TH, Hoebel BG. Excessive sugar intake alters binding to dopamine and mu-opiod receptors in the brain. Neuroreport. 2001 Nov 16;12(16):3549-52.

  20. Emond, M., Ladenheim, E.E., Schwartz, G.J., Moran, T.H. Leptin amplifies the feeding inhibition and neural activation arising from a nutrient preload. Physiol Behav. 72(1-2)123-128, 2001.

  21. Emond, M., Schwartz, G.J., Moran, T.H. Meal-related stimuli differentially induce c-Fos activation in the nucleus of solitary tract. Am M Physiol Regul Integr Comp Physiol 280(5):R1315-21, 2001.

  22. Hansel, D.E., Eipper, B.A., Ronnett, G.V. Neuropeptide Y functions as a neuroproliferative factor. Nature 410(6831):940-944, 2001.

  23. Krasnova IN, Ladenheim B, Jayanthi S, Oyler J, Moran TH, Huestis MA, Cadet JL. Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation. Neuroscience. 2001;107(2):265-74.

  24. Moran TH, Ladenheim EE, Schwartz GJ. Within-meal gut feedback signaling. Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S39-41. Review.

  25. Schilling G, Jinnah HA, Gonazales V, Coonfield ML, Kim Y, Wood JD, Price DL, Li XJ, Jenkins N, Copeland N, Moran TH, Ross CA, Borchelt DR. Distinct behavioral and neuropathological abnormalities in transgenic mouse models of hd and drpla. Neurobiol Dis. 2001 Jun;8(3):405-18.

  26. Srinivasan, A., Kraus, C.N., DeShazer, D., Becker, P.M., Dick, J.D., Spacek, L., Bartlett, J.G., Byrne, W.R., Thomas D.L. Glanders in a military research microbiologist. New England Journal of Medicine. 345(4):256-258, 2001.

  27. Lin, H.Z., Yang, S.Q., Chuckaree, C., Kuhajda, F., Ronnet, G., Diehl, A.M. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med. 6(9):998-1003, 2000.

  28. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288:2379-2381, 2000.

  29. Moran, T.H., Wirth, J.B., Schwartz, G.J., McHugh, P.R. Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying. Am J Psysiol 276(4 Pt 2):R997-R1002, 1999.
Copyright © 2008 FASgen, Inc.